Suppressing the secretion of exosomal miR-19b by gw4869 could regulate oxaliplatin sensitivity in colorectal cancer
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چکیده
منابع مشابه
miR-19b-3p promotes colon cancer proliferation and oxaliplatin-based chemoresistance by targeting SMAD4: validation by bioinformatics and experimental analyses
BACKGROUND As a disease with extremely complex molecular mechanisms, many deregulated miRNAs have been identified in colon cancer. Few studies have been performed by using Ingenuity Pathways Analysis (IPA) to predict miRNAs specifically expressed in colon cancer. METHODS A characteristic microRNA-target network of colon cancer was explored using IPA. Then the clinical significance of miR-19b-...
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this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...
Cetuximab sensitivity associated with oxaliplatin resistance in colorectal cancer.
BACKGROUND Clinical studies have suggested that the epidermal growth factor receptor (EGFR)-inhibiting antibody cetuximab may have better effect in the third-line treatment of metastatic colorectal cancer, after failure of standard chemotherapy including oxaliplatin, compared to using it up-front in the first line. The reason behind this suggestion is unclear. MATERIALS AND METHODS The effect...
متن کاملMiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells Running title: miR-19b/20a/92a regulate self-renewal
1 State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an, Shaanxi, 710032,China 2 Ningxia Medical University Affiliated Hospital, Yinchuan, Ningxia, 750004, China. 3 These authors contributed equally to this work. Correspondence State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military M...
متن کاملmiR-195 enhances the radiosensitivity of colorectal cancer cells by suppressing CARM1
BACKGROUND microRNAs (miRNAs) can regulate the sensitivity of cancer cells to chemotherapy and radiotherapy. Aberrant expression of miR-195 has been found to be involved in colorectal cancer (CRC); however, its function and underlying mechanism in the radioresistance of CRC remains unclear. METHODS The levels of miR-195 and CARM1 were detected by quantitative reverse transcription-polymerase ...
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ژورنال
عنوان ژورنال: Neoplasma
سال: 2019
ISSN: 1338-4317
DOI: 10.4149/neo_2018_180306n155